Concept of an Agent-stress Model of a Tissue

Abstract

This paper stands for a concept of coupling between agent modeling and stress analysis valid for a tissue. The stress analysis of evolving tissue is underestimated in previous studies. The experimental observations and numerical simulations of stress development in a single cell and in particular, in a growing tissue are still rare in the literature. We use a tensegrity model for a single cell that serves for stress evaluation in a growing tissue. We propose to couple the mechanical modeling with the agent one using a staggered scheme for two exemplary scenarios. The first example is devoted to scratching of the epithelium, and the second one to the pins and slits. We observe the systems sensitivities with respect to the selected groups of design parameters. The groups of parameters have been associated with clusters of cells. We have found that the sensitivities may be used for comparing the complex structures of the tissue.